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New Generation Andrology Tests

New Generation Andrology Tests

Sperm DNA Damage Panel

  • Spermiogram
  • Determination of oxidative stress in semen (ROS Analysis)
  • Sperm DNA damage test

Haploidy panel from TESA

  • Sperm FISH in TESA tissue
  • Determination of spermatogenesis marker in TESA tissue  (LIM15, ESX1, TEX101,PCNA)

Haploidy panel in semen

  • Sperm FISH in semen
  • Determination of spermatogenesis marker in semen  (LIM15, ESX1, TEX101,PCNA)

Post meiotic semen panel

Apoptosis Determination in semen

Sperm test

Sperm test, defined as a spermiogram, is a laboratory test to measure the quantity and quality of healthy sperm cells in semen. In men, the sperm cells are analyzed during ejaculation with the help of this test to assess the male's reproductive potential. Although the couples who want to have children have sexual intercourse regularly and unprotected for a year, sperm test is one of the first tests when pregnancy cannot be achieved. Thus, the presence and quantity of the motile and healthy sperm cell required for reproduction is analyzed.

Advantages of Sperm DNA Damage Test

Sperm DNA damage, beyond routine sperm sample assessment, provides a reliable analysis that can help identify whether a healthy pregnancy can occur. The obtained information helps in the clinical diagnosis and treatment of male infertility.

Who should need sperm DNA fragmentation test?

  • Unexplained Infertility Cases,
  • Couples with slow embryo development,
  • Patients with abnormal embryo development,
  • Recurrent IVF / ICSI failure
  • Recurrent Pregnancy Loss
  • Patients with oligoasthenoteratozoospermia and severe teratozoospermia, especially on spermiogram.

Causes of Sperm DNA Damage

In men, the most important factor of sperm DNA damage is oxidative stress. In normal oxidative metabolism, a low degree of hydrogen peroxide is required for sperm production. At normal levels, balance ROS is necessary for sperm capacitation during fertilization. The measurement of ROS and DNA damage in male subfertility and its clinical effect is an issue that increases the emphasis on success in assisted reproductive treatment methods. Determination of sperm DNA damage, seminal oxidative stress and antioxidant levels is important for deciding which reproductive treatment methods will be used.

Other Causes;

  • Infection
  • Fever
  • High testicular temperature
  • Use of recreational drugs
  • Smoking
  • Alcohol
  • Excessive caffeine consumption
  • Stress
  • Diet
  • Environmental and occupational pollutants
  • Advanced age
  • Varicocele
  • Leukocytospermia
  • History of chemotherapy and radiotherapy