Oncocept

What is Oncocept?

Oncocept is an advanced genetic testing panel that analyzes a large number of genes associated with cancer. This test uses modern technologies such as NGS (Next Generation Sequencing) to identify mutations that may help with diagnosis, prognosis, and treatment selection.

Oncocept Panels

  • Oncocept Solid 52 Gene Panel – analysis of 52 genes associated with solid tumors.
  • Oncocept Solid Comprehensive – 206 Gene – comprehensive profiling of 206 genes using DNA + RNA.
  • Oncocept Solid CGP – 590 Gene Panel – comprehensive genomic profiling for the analysis of a wide range of genetic alterations.
  • Oncocept Solid 206 Genes + MSI + Tumor Burden – analysis of 206 genes combined with assessment of MSI and Tumor Mutational Burden (TMB).
  • Oncocept Solid 206 Genes + MSI by PCR – analysis of 206 genes together with MSI testing using the PCR method.

Oncocept Liquid Panels

  • Oncocept Liquid – 11 Gene Panel
  • OncoCEPT-Liquid Plus – 45 Gene Panel
  • OncoCEPT Liquid Comprehensive – 206 Gene Panel

These panels analyze circulating tumor DNA in the blood (ctDNA) and may provide molecular information without requiring material to be collected directly from the tumor, when clinically appropriate.

Specialized Tests and Panels

  • Oncocept TMB – assessment of tumor mutational burden.
  • Oncocept GIST – molecular profiling for gastrointestinal stromal tumors.
  • Oncocept CNS – a panel focused on tumors of the central nervous system.
  • Oncocept Thyroid – molecular analysis for thyroid tumors.
  • Oncocept Sarcoma – a panel for the molecular characterization of sarcomas.
  • ColoComprehensive – comprehensive panel for colorectal tumors.
  • Oncocept Lung Panel – a panel dedicated to lung tumors.
  • Oncohaem DNA Only by NGS – molecular analysis of hematological diseases at the DNA level.
  • Oncohaem PLUS by NGS – a panel for identifying SNVs and small indels in hematological diseases.

Why is Tumor Genetic Profiling Used?

Molecular profiling may help the medical team with:

  • identifying mutations and genetic alterations in the tumor;
  • identifying biomarkers such as MSI and TMB;
  • identifying alterations that may be important for targeted therapies;
  • providing a more detailed characterization of tumor biology;
  • supporting treatment decisions for personalized care.

Test results are always interpreted in the context of the diagnosis, clinical history, histopathological findings, and the oncologist’s assessment.

What Does It Analyze?

Depending on the selected panel, OncoCEPT can analyze a wide range of genetic alterations, including:

  • SNV (Single Nucleotide Variants) – changes involving a single DNA base.
  • Small Indels – small insertions or deletions.
  • CNV (Copy Number Variations) – changes in the number of copies of genes.
  • Gene Fusions / Rearrangements – gene fusions or rearrangements.
  • TMB (Tumor Mutational Burden) – assessment of the number of mutations present in the tumor.
  • MSI (Microsatellite Instability) – assessment of microsatellite instability.
  • In panels that include RNA, changes expressed at the RNA level can also be identified, particularly gene fusions.

The combination of DNA + RNA may provide a more comprehensive molecular profile of the tumor.

 

How Is the Sample Collected?

For OncoCEPT Solid

In most cases, tumor tissue is used, often an FFPE (Formalin-Fixed Paraffin-Embedded) block obtained from a biopsy or surgical procedure.

Some laboratories also specify the use of fresh tissue under appropriate transportation conditions.

For OncoCEPT Liquid

A blood sample is used, from which circulating tumor DNA (ctDNA) is analyzed.

For OncoHAEM

Depending on the panel and hematological condition, the sample may be peripheral blood. The type of sample is determined according to the requested panel and the recommendation of the laboratory or physician.

Results

The Oncocept™ test is analyzed at Neuberg Diagnostics, a laboratory specializing in molecular diagnostics.

Test results are available within 40 business days.

 

 

FAQs

01

What is the Oncocept test?

 

Oncocept™ is an advanced genetic test that analyzes genetic alterations associated with tumors, providing molecular information that may help physicians assess and manage the disease.

02

What does the Oncocept™ test analyze?

 

The test analyzes a broad panel of genes to identify genetic alterations that may be relevant to the molecular characterization of the tumor and to guide further therapeutic decisions.

03

Who is the Oncocept™ test recommended for?

 

The test may be recommended for patients diagnosed with a tumor, particularly when molecular information may help determine further treatment options. The recommendation is made by the physician based on the individual clinical case.

04

What type of biological material is used for the test?

 

Depending on the case and the available material, the analysis may be performed using tumor tissue obtained during diagnostic or surgical procedures. The physician or laboratory determines the appropriate material for analysis.

05

Where is the Oncocept™ test analyzed?

 

Samples for the Oncocept™ test are analyzed at Neuberg Diagnostics.

06

How long does it take to receive the results?

 

Test results are available within 40 business days.

07

Is Oncocept™ a diagnostic test for cancer?

 

Oncocept™ does not replace histopathological examination and clinical assessment. It provides molecular/genetic information that is interpreted together with the patient’s other clinical data.

08

Can the result be used to determine treatment?

 

The result may provide important information for the physician when assessing the molecular characteristics of the tumor and considering therapeutic options. Treatment decisions are made by the specialist physician.

09

Is a consultation with a physician required before the test?

 

Yes. It is recommended that the test be performed after an assessment by a specialist physician, who determines whether the analysis is appropriate for the clinical situation.

10

How can I have the Oncocept™ test performed through Pentagene Genetics?

 

For information about the procedure, required material, and sample submission, please contact Pentagene Genetics before having the test performed.